Abstract: To take full advantage of the structural characteristics of multi-core clusters and enhance the use of CPU each core efficiently, a multi-core cluster hybrid parallel programming model is constructed. The model combines the shared memory and the TBB task-oriented programming and MPI message-passing programming mode. Using their advantages, achieve the hierarchical parallel programming of processes to nodes and threads to the processor core. Compare with the algorithm of the single parallel programming model, this programming mode not only can reduce the program execution time, get a better speedup and execution efficiency, but also improve the cluster performance greatly.