Abstract: A charge-balanced programmable pulse generator is proposed. This circuit has overcome the problem that the amount of charges pass through cardiac unequal between charge and stimulate phase, and deduces the security risk. This circuit mainly includes a high efficiency charge pump circuit, DAC and pulse control circuit based on comparator, and its adjustable character suits for different patients. This circuit is based on HHNEC 0.35 BCD technology and simulated through Spectre.