Abstract: During constructing the Collaborative Computing between Central Process Unit and Graphic Process Unit or Central Process Unit and other device.Through the Peripheral Component Interconnect connects Graphic Process Unit and Central Process Unit,it's responsiable for doing the parrallel computing. Point at the asyncronous transmission and timing matched in the connection of Peripheral Component Interconnect IP core and the Graphic Process Unit,based on the standard of the Peripheral Component Interconnect and the Graphic Process Unit chip, use the method of processing asyncronous signals,this paper design an timing matched interface circuit between the Central Process Unit and Graphic Process Unit,which aims at the different clock systems and the timing matced of them.The simulation results prove that the interface circute between Central Process Unit and Graphic Process Unit can works at 252 M Hz frequency,it achieves the circuit demand,and realize high-speed data transmission between Graphic Process Unit and Central Process Unit.