Abstract: In order to overcome the problem of low transmission efficiency of multi-processor systems and meet the requirements of high-resolution video real-time encoding and transmission. Proposes a design method of video transmission system based on single-chip FPGA+ARM processor. Using FPGA to complete video capture and encoding; using ARM to implement bitstream encapsulation and transmission. The method take full advantage of FPGA processing mass data and the design resources of ARM, achieve a high efficiency video transmission system in a small volume, compared with the systems built by multi-processor, this system has higher integration and flexibility. Test results show that the system runs smoothly and can basically achieve real-time video encoding and transmission.