Abstract: RF power amplifier is the core component of wireless communication system, it′s output power and added efficiency are important and difficult to design.The consistent of output power and power added efficiency can′t achieved with existing methods.Considering the influence of harmonic, load and source impedance on output power and power added efficiency, by using multi-harmonic bilateral pull technology, design a high-efficiency RF power amplifier.Simulation results show that when the additional efficiency at best, the output power is also high, fully meet the design requirements.