Abstract: In order to make the data communication between the computer and ARINC 429 bus more easy and fast, An ARINC429 bus communication interface based on USB bus is designed.With modular method, this design integrates the data buffer module and USB communication interface module in one FPGA chip,and a ESD protection circuit is designed.The integrated design and the operational principle of the interface are given.After the testing, the result corresponds with the design demand,and implement the reliability and portability of interface.