Abstract: Block Cyclic Redundancy Check (CRC) can meet the requirement of high-speed link. To overcome the drawbacks of the present CRC computation method which based on calculation of polynomial and lookup table, a fast configuration method was proposed. First of all, CRC parallel calculation method is derived by state matrix. According to the matrix exchanging, combined remainder calculation with remainder transformation to simplify the computation process. Multilevel block CRC computation is a hybrid method of multichannel and parallel width in which generator polynomial, the number of channels and the width of parallel processing can set arbitrarily. Simulation results show that new method can further improve the performance of CRC's computation, increasing number of channels is more efficient than expanding parallel width.