Abstract: Spacecraft cabin layout CAD system is the intelligent layout design system that makes some layout and optimization for a variety of devices and equipment in a spacecraft cabin.In this paper, using axiomatic design method to carry on the design for the spacecraft cabin layout CAD system, and proposing the design process based on the independence axiom, getting the functional structure chart of the system, it can reduce the complexity of the design, make rational decisions with the proper sequence in the design process and ensure the efficiency and rationality of the system.