Abstract: In wireless spread spectrum communication in the modulation signal transmission is easily affected by the multi-path effect of multipath channel generated intersymbol interference, the error increases, the signal transmission distortion, a modulation signal transmission wireless spread spectrum communication system passive time reversal technique stem interference suppression method based on lossless transmission of communication signals, the first building the multipath channel model of wireless spread spectrum communication, channel equalization design using fractionally spaced equalization technology, the passive time reversal mirror method to suppress intersymbol interference and blind source separation, improve the ability of modulation signal lossless transmission wireless spread spectrum communication system. Finally, through the simulation experiment of performance test results show that by using this method in the design of wireless spread spectrum communication system, channel equalization performance better, intersymbol interference can be effectively suppressed, the communication error rate is lower than the traditional method.