Abstract: Dynamic reconfigurable high-speed serial bus (UM-BUS) has the characteristics of concurrent lanes redundancy and remote memory accessing capabilities. However, traditional fixed network structure does not meet the requirements of dynamic access and multi-source information fusion for the heterogeneous resources of CPS and Internet of things. To solve the problem of plug and play and real-time response of UM-BUS modules, this paper presents a method of interrupt request and arbitration with low cost and high efficiency. It adopts encoding arbitration to fulfill the interrupt handling of UM-BUS devices. This method can satisfy the requirements of event interrupt notification and real-time response between UM-BUS devices in the CPS or Internet of things application environment.