Abstract:
Chronic diseases like cancer, diabetes, heart disease, epilepsy, and hypertension have become the leading causes of death in China, with 70% of the healthcare burden. Compared with traditional drug delivery methods such as oral administration and injection, implantable precision-targeted therapy has been proven to be an effective treatment for chronic diseases, with rapid results and virtually no side effects, as well as on-demand and precise dosage. At present, China is just in the beginning in this field, especially in high-end micro-nano integrated System on Chip(SoC) chips, micro-nano system integration and packaging reliability, etc. Original technology is not enough in China. Therefore, it is necessary to promote the development of high-end medical devices from the source of innovation by breaking through relevant key common technologies, localization of core components, to accelerate the industrialization of medical devices and break the monopoly of developed countries. This research aims to break through the key common technologies of micro-nano integrated chips and integrated systems for medical devices, and solves the problems of small size, high precision, and low power consumption of microelectronics. The implantable precision targeted drug delivery system and vagus nerve stimulator are constructed through three-dimensional heterogeneous integration, realizing the functions of precision targeted drug delivery, wireless charging, bioelectrical signal acquisition, and electrical stimulation, etc. The prototype of the project has been verified by biocompatibility tests and animal experiments.
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