Abstract: This paper introduces a high-side power drive circuit using a floating structure, including an input stage circuit, a voltage stabilization circuit, a floating generation circuit, and a charge pump-based drive circuit.A new solution and circuit design method are proposed for the ground signal interference, signal crosstalk problem and voltage regulator source circuit existing in the traditional drive circuit, which greatly improve the stability of high-side power drive circuits.Based on BCD process, the simulation results under the condition of single power supply in the range of 7V ~ 40V show that the floating circuit can work normally at the frequency of 2MHz oscillator, and the ripple voltage variation on the floating ground is less than 0.03V. Moreover, it can filter the interference signal effectively, and has a strong ability to prevent error triggering. This new floating circuit and voltage regulator circuit can be well used in high side power drive circuit.