Abstract: This paper presents a back-end digital calibration technology, which is based on LMS algorithm and can iterates first- and third-order error coefficients automatically. The calibration technology can reduce the influence of capacitive mismatch, op amp limited gain and other nonlinear factors, and improve linearity of the system effectively. The entire digital calibration system was modeled with Simulink. The simulation results showed that the ENOB, SNR, and SFDR of the pipeline ADC with sampling rate of 100 MHz and input rate of 45 MHz were improved from 9.6 bit to 15.7 bit, 67.5 dB to 97.6 dB and 64.9 dB to 110.8 dB respectively after calibration.