Abstract: To deal wth the problems of network topology change caused by node mobility, new nodes joining network, and node failure that impacted on network performance in mobile wireless sensor networks (MWSN). Weighted clustering based topology maintenance algorithm (WCTMA) was proposed in this paper.Firstly, the nodes'weights were calculated based on the mobility and surplus energy, the network was clustered according to the nodes'weights.Secondly, the control messages of transmission and reception between nodes was used to judge whether the network topology has changed.Finally, cluster topology maintenance strategy and inter-cluster topology maintenance strategy were designed according to the different factors that cause the network topology change.The simulation results show that the WCTMA algorithm has significantly improved compare with FDRC algorithm in average node residual energy, network connectivity degree and lifetime of network.